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§ 121
In proving
medicines to ascertain their effects on the healthy body, it must
be borne in mind that the strong, heroic substances, as they are
termed, are liable even in small doses to produce changes in the
health even of robust persons. Those of milder power must be given
for these experiments in more considerable quantities; in order
to observe the action of the very weakest, however, the subjects
of experiment should be persons free from disease, and who are delicate,
irritable and sensitive.
§ 122
In these
experiments - on which depends the exactitude of the whole medical
art, and the weal of all future generations of mankind - no other
medicines should be employed except such as are perfectly well known,
and of whose purity, genuineness and energy we are thoroughly assured.
§ 123
Each
of these medicines must be taken in a perfectly simple, unadulterated
form; the indigenous plants in the form of freshly expressed juice,
mixed with a little alcohol to prevent it spoiling; exotic vegetable
substances, however, in the form of powder, or tincture prepared
with alcohol when they were in the fresh state and afterwards mingled
with a certain proportion of water; salts and gums, however, should
be dissolved in water just before being taken. If the plant can
only be procured in its dry state, and if its powers are naturally
weak, in that case there may be used for the experiment an infusion
of it, made by cutting the herb into small pieces and pouring boiling
water on it, so as to extract its medicinal parts; immediately after
its preparation it must be swallowed while still warm, as all expressed
vegetable juices and all aqueous infusions of herbs, without the
addition of spirit, pass rapidly into fermentation and decomposition,
whereby all their medicinal properties are lost.
§ 124
For these
experiments every medicinal substance must be employed quite alone
and perfectly pure, without the admixture of any foreign substance,
and without taking anything else of a medicinal nature the same
day, nor yet on the subsequent days, nor during all the time we
wish to observe the effects of the medicine.
§ 125
During
all the time the experiment lasts the diet must be strictly regulated;
it should be as much as possible destitute of spices, of a purely
nutritious and simple character, green vegetables,1 roots and all
salads and herb soups (which, even when most carefully prepared,
possess some disturbing medicinal qualities) should be avoided.
The drinks are to be those usually partaken of, as little stimulating
as possible.2
1 Young green peas,
green French beans (‘boiled potatoes’ in the Sixth Edition)
and in all cases carrots are allowable, as the least medicinal vegetables.
2 The subject of
experiment must either be not in the habit of taking pure wine,
brandy, coffee or tea, or he must have totally abstained for a considerable
time previously from the use of these injurious beverages, some
of which are stimulating, others medicinal.
§ 126 Fifth Edition
The person
who is proving the medicine must during the whole time of the experiment
avoid all over-exertion of mind and body, all sorts of dissipation
and disturbing passions; he should have no urgent business to distract
his attention; he must devote himself to careful self-observation
and not be disturbed while so engaged; his body must be in what
is for him a good state of health, and he must possess a sufficient
amount of intelligence to be able to express and describe his sensations
in accurate terms.
§ 126 Sixth Edition
The person
who is proving the medicine must be pre-eminently trustworthy and
conscientious and during the whole time of the experiment avoid
all over-exertion of mind and body, all sorts of dissipation and
disturbing passions; he should have no urgent business to distract
his attention; he must devote himself to careful self-observation
and not be disturbed while so engaged; his body must be in what
is for him a good state of health, and he must possess a sufficient
amount of intelligence to be able to express and describe his sensations
in accurate terms.
§ 127
The medicines
must be tested on both males and females, in order also to reveal
the alterations of the health they produce in the sexual sphere.
§ 128 Fifth Edition
The most
recent observations have shown that medicinal substances, when taken
in their crude state by the experimenter for the purpose of testing
their peculiar effects, do not exhibit nearly the full amount of
the powers that lie hidden in them which they do when they are taken
for the same object in high dilutions potentized by proper trituration
and succussion, by which simple operations the powers which in their
crude state lay hidden, and, as it were, dormant, are developed
and roused into activity to an incredible extent. In this manner
we now find it best to investigate the medicinal powers even of
such substances as are deemed weak, and the plan we adopt is to
give to the experimenter, on an empty stomach, daily from four to
six very small globules of the thirtieth potentized dilution of
such a substance, moistened with a little water, and let him continue
this for several days.
§ 128 Sixth Edition
The most
recent observations have shown that medicinal substances, when taken
in their crude state by the experimenter for the purpose of testing
their peculiar effects, do not exhibit nearly the full amount of
the powers that lie hidden in them which they do when they are taken
for the same object in high dilutions potentized by proper trituration
and succussion, by which simple operations the powers which in their
crude state lay hidden, and, as it were, dormant, are developed
and roused into activity to an incredible extent. In this manner
we now find it best to investigate the medicinal powers even of
such substances as are deemed weak, and the plan we adopt is to
give to the experimenter, on an empty stomach, daily from four to
six very small globules of the thirtieth potency of such a substance,
moistened with a little water or dissolved in more or less water
and thoroughly mixed, and let him continue this for several days.
§ 129
If the
effects that result from such a dose are but slight, a few more
globules may be taken daily, until they become more distinct and
stronger and the alterations of the health more conspicuous; for
all persons are not effected by a medicine in an equally great degree;
on the contrary, there is a vast variety in this respect, so that
sometimes an apparently weak individual may by scarcely at all affected
by moderate doses of a medicine known to be of a powerful character,
while he is strongly enough acted on by others of a much weaker
kind. And, on the other hand, there are very robust persons who
experience very considerable morbid symptoms from an apparently
mild medicine, and only slighter symptoms from stronger drugs. Now,
as this cannot be known beforehand, it is advisable to commence
in every instance with a small dose of the drug and, where suitable
and requisite, to increase the dose more and more from day to day.
§ 130
If, at
the very commencement, the first dose administered shall have been
sufficiently strong, this advantage is gained, that the experimenter
learns the order of succession of the symptoms and can note down
accurately the period at which each occurs, which is very useful
in leading to a knowledge of the genius of the medicine, for then
the order of the primary actions, as also that of the alternating
actions, is observed in the most unambiguous manner. A very moderate
dose, even, often suffices for the experiment, provided only the
experimenter is endowed with sufficiently delicate sensitiveness,
and is very attentive to his sensations. The duration of the action
of a drug can only be ascertained by a comparison of several experiments.
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