Introduction
Bromide of sodium, Na Br.
Provings
1. During course of an e. I took 25 gr. on an empty stomach, in two doses of 10 and one of 5 gr., at 1/2 h. intervals. The effect on pulse and temperature was negative; upon retiring to rest as usual, I experienced a somewhat pleasant drowsy sensation and slept remarkably well, though I awoke several times during the n., as is customary with me. Towards m., however, I felt a numbness and tingling in both forearms and in my l. leg, which did not entirely disappear for some h. subsequently. I ought to state that shortly after each dose I experienced a burning sensation at the epigastrium, which quickly passed off. (HOLLIS, Pract. xi, 81)
2. LABORDE took 16 grms., and experienced thirst, salivation, great wish to sleep, stupor on walking, melancholy, vertigo – ground under his feet seemed to move, ataxia, slow pulse, loss of power of will, and insensibility of throat. (A. h. Z., lxxxvii, 46. – Referred to Arch. de Physiol. for 1869, but not to be founded there.).
Experiments on animals
1. Haemadynamometer was connected with femoral artery of cocker- dog; 50 gr. bromide of sodium, in 3ij water, into jugular. Mercury, whose highest mark was 2 3/4 in., fell directly to level, and remained there 60 seconds, no oscillations distinguishable. In 1 min. after injection, column began to rise, and soon regained former level, oscillations less frequent, but stronger than before operation. 4 min. after operation, heart seemed restored; he was set loose. Had lost power of moving limbs, but retained consciousness. Pupil dilated. Heart’s action became synchronous with respiration, being 54 in minute. One h. after operation was in same state, but gradually recovered. (GLOVER, loc. cit.)
2. A hundred gr., in 3iij water, were thrown into jugular of terrier bitch (large and strong). Only symptom was much quickened and excited heart. Animal on being set loose seemed lively and excited. (Ibid.) [ For other bromides, see the substances with which the B. is compounded.- EDS.