Quinine is, above all, a protoplasmic poison, devitalizing the blood and tissues; it particularly retards the elimination of nitrogenous waste (urea and uric acid), and causes the retention and accumulation of effete products in the system (though for a time the diminished waste gives a sense of “tone” to the system, the ultimate result is deplorable). It causes congestion of the brain, and, in large doses, abolishes the cerebral functions. It is an irritant to serous membranes and to the skin, it causes deafness and serous inflammation of the internal ear; blindness, ischaemia of the retina and optic neuritis; it produces stupor, delirium and even convulsions. (Epilepsy is intensely aggravated by it.) Quinine, however, arrests the development of low forms of vegetable life, and especially of the poison of marsh malaria, but it rarely antidotes the effects of the poison on the system.
Pains in various parts of the body, paralytic tearings, especially in the extremities, joints, bones and periosteum, sometimes worse in the spine and small of the back. Pain, as after fatigue, or like exhaustion from bleeding or profuse loss of semen. Pain in joints when sitting and lying, with restlessness. Tensive drawing pains in almost all the bones, now one, now another, (>) momentarily by lying, then more violent than ever. Attacks of pain excited even by light touch of the part, and then frequently increasing to a frightful severity. Parts upon which he lies fall asleep. Weakness, as after loss of the various fluids of the body, with oversensitiveness of all the senses and nerves; an inclination to perspire. Most extreme powerlessness and exhaustion. Nausea; emaciation. Oppression of all parts, as if the clothes were too tight, especially after a walk in the open air. Joints feel heavy in the morning in bed, (>) rising. Aversion to all mental and physical effort. The slightest draft of air brings on the troubles. General aggravation at night. Dropsical swellings.
Clinical. Anaemia, with extreme debility from nursing or from loss of blood. Rapid emaciation, with indigestion, voracious appetite, undigested stools, copious night-sweats. Purpura haemorrhagica after nursing, with roaring in ears, cold, clammy skin, painless diarrhoea. which may be bloody. Leucocythemia.
Excitability, with intolerance of noise. Sudden screaming and tossing about. Solicitude about trifles. Discontented mood. Anxiety in the morning on waking. Ill humored and easily offended quarrelsome. Gloominess alternating with cheerfulness. General disinclination to mental labor; with sleepiness. Unable to arrange his thoughts; makes mistakes when writing or speaking, reverses his words easily; disturbed by the talking of others. Ideas flow slowly.
General sensation of confusion and fulness, as though the blood rushed to the head. Pressing headache, as if the skull would burst. The brain seems to beat in waves against the skull. A feeling as though the brain were pressing together from both sides and out at the forehead, (<) walking in the open air. Pain deep in the brain, (<) walking, with a feeling of constriction, worse in the right side of the forehead and in the occiput. Forehead is not, with cold limbs. Frontal headache worse on turning the eyes, with heat and jerking pain in the temples. Vertigo on walking at night; cannot sit upright; head inclines to sink backward, (<) motion and walking (>) lying. Pressing headache in the temples, worse at night. Pulsation in the temples, (>) hard pressure, (<) movement. Jerking pains in the temples, extending to the upper jaw. General bruised pain over the whole head, (<) mental effort. Scalp sensitive to touch.
Sensation of foreign body in the eye, with inflammation and heat, worse in the evening. Whites of the eyes are yellow. Pupils dilated (sometimes contracted). Transient blindness, with flickering before the eyes.
Clinical. Retinal asthenopia, with transient blindness or with flickering before the eyes (after sexual excesses). Hemeralopia. Neuralgia above the eyes; ciliary neuralgia, supraorbital neuralgia (Ced.); the neuralgia aggravated by slightest touch. The weakness of vision and the neuralgia above the eyes are frequently associated with spinal irritation and great soreness of the spine, extending into the occiput and even into the eyes; the pains frequently aggravated at night when lying down, but not always.
Ringing in the ears, with pain in the temples. Roaring. Ticking as of a watch. Deafness as if ears were stopped. Tearing pains, (<) least touch.
Clinical. Ringing and roaring in the ears, loss of hearing. Frequent neuralgic pains in ears, aggravated by touch. Hearing extremely sensitive to noise. External ear very sensitive to touch, sometimes inflamed. Haemorrhage from the ears, sometimes with purulent discharge, even offensive.
Pain in the root of the nose, extending to the side after the heat of the cheek had disappeared. Sneezing. Fluent coryza, with sneezing and lachrymation; watery discharge, with stoppage. Bleeding of the nose after excesses, relieving the headache.
Pale and sunken. Yellowish, earthy-colored. Facial neuralgia, (<) slight touch. Face sometimes red, inflamed, like erysipelas. Lips dry, cracked, even blackish.
Teeth loose; painful on chewing. Toothache, jerking tearing in upper back teeth, (>) biting the teeth together and pressure for a moment, (<)cold air, in a draft. Mouth disagreeable in the morning; much mucus collects; tongue is yellow, dirty-white, somewhat swollen. Burning stitches in the tongue. Dryness in the mouth. Salivation. Tastes bitter; better for a while after eating. Bread tastes bitter when swallowing, though not when chewing. Slimy taste, so that he has a disgust for butter. Taste sweet, then sour. In general, salivation and more or less nausea.
Unnatural appetite. Desire for all sorts of things, he hardly knows what. Desire for sour fruit, then indifference to eating and drinking. Aversion to coffee. Extreme thirst, but drinks little. Thirst, drinking followed by coldness and rumbling in the abdomen; especially after the chill. Thirst during the sweating stage. Eructations of gas; sour. Soreness in the pit of the stomach in the morning, with pain as from pressure on a sore place. Pressure after eating a little. Flatulence in the stomach for a long time after a meal, as though he had just eaten. Gastric derangements caused by milk.
Clinical. Dyspepsia; constant satiety, with coldness in stomach, craving for pungent spices and sour things and stimulants; digestion extremely slow; after eating he feels full, drowsy; taste of the food rises, with dyspnoea, etc. Dyspepsia, with painful pressure and distention in region of stomach after eating and drinking a little. Appetite entirely lost, and after eating a little loud belching and inability to work. Acid dyspepsia, heartburn even after milk, constant satiety, no relief from belching gas. After haemorrhage from the stomach, with great sensitiveness of the stomach and great prostration, etc.; the abdomen sensitive over the region of the liver, which is sometimes swollen (compare gastric symptoms with Lycopodium).
Distention after eating. Fermentation from fruit. Painfulness over the region of the liver, especially to light touch. Swelling and induration of the liver. Sticking pains in the region of the spine. Colic in the abdomen before a stool, with thirst. Colic in the abdomen, with shivering. Flatulent colic, with tension and anxiety in the upper abdomen, and with a feeling as if the lowest intestines were constricted.
Diarrhoea of undigested feces. Diarrhoea, with biting, burning pain in the anus, preceded and followed by colic.
Clinical. Painless diarrhoea, with bloated abdomen, stools containing undigested food; aggravated at night, with great fermentation in bowels, general desire for acids and relishes of various sorts. Stools sometimes involuntary, of cadaverous odor. Diarrhoea from eating fruit. Diarrhoea recurring after meals. Diarrhoea occurring in the course of debilitating diseases. Dysentery, rarely.
Pressure in the bladder follows frequent and perhaps ineffectual efforts to urinate. Urine dark, with brick-red sediment. Urine rather copious. Burning in the orifice of the urethra.
Sexual Organs, Male
Generally excited sexual desires. Seminal emissions frequent, but ejaculations too easy, followed by extreme weakness.
Sexual Organs, Female
A feeling of rush of blood to the uterus, with painful heaviness in the pelvis.
Clinical. Impotency resulting from sexual excesses; nocturnal emissions, very debilitating; in general, frequently useful for symptoms resulting from sexual excesses. Uterine haemorrhages, especially after labor, with atony of uterus, discharge of large quantities of blood, cold skin, fainting, convulsive jerks, etc. Menstruation too early and profuse, with dark clots, distention of abdomen, etc. Leucorrhoea that comes on instead of the menses; bloody, fetid, purulent, great weakness, etc. Metritis. Ovaritis from sexual excesses or following haemorrhages; all the parts are very sensitive to the slightest, touch. General anaemia, resulting from prolonged nursing. Haemorrhage from the lungs while nursing. Painful indurations in the vagina, in consequence of excessive sexual gratification.
Whistling and wheezing in trachea on breathing. Voice deep and rough, with hoarseness, as from sometimes adhering to the larynx. Cough caused by laughing; after eating; as from sulphur fumes. Suffocative attacks, as if the larynx were full of mucus, worse towards evening and at night on waking. Oppression of the chest, as though from fulness in the stomach, or caused by long talking.
Sticking pains in the cartilages of third and fourth false ribs. A feeling of fulness like a rush of blood to the chest, with violent palpitation.
Palpitation, with a rush of blood to the face, which was hot and red, with cold hands; with intermitting pulse.
Neck and Back
Pain in the nape of the neck, as from swelling, (<) touch. Pressure, as from a stone between the scapulae. Pain in the small of the back at night when lying on back. Tensive pain in the sacrum, as from a heavy load or after long stooping. Tensive pain in the small of the back as from cramp or as if bruised and crushed, with sudden crying out on motion.
Jerking pains, (<) touch. Trembling. Laxity of all the extremities and trembling of the hands; tremulous weakness. Heaviness as if lead were hanging to them. Paralytic stiffness in all the joints on rising in the morning, or after midday nap, with depressed spirits. Falling. or asleep of the limbs on which he lies. Sensation of a band tied tightly around different parts.
Paralytic jerking-tearing in long bones, (<) touch. Paralytic jerking-tearing on top of shoulder, with sensitiveness to touch, the pain renewed by touch, even of coat. Paralytic jerking- tearing extending from head of humerus along muscles and bones to phalanges, where it is painless, the pain (<) touch, with weakness of whole arm. Paralytic pain in head of right humerus, extending to the hand, like a tearing. Trembling of the hands when writing. Tearing in bones of right distal phalanges, especially of the joints.
Drawing pains in bones, as if periosteum had been scraped. Hot swelling of right knee. Weakness in the knees. Swelling of the feet. Sensation as if garters were too tight, and leg would go to sleep or were numb. Jerking-tearing in metatarsal bones and in toes, (<) touch. Weakness of the feet as if bruised.
Sensitiveness of the whole skin, even of the palms. Yellowness of the skin.
Overpowering sleepiness during the day, when sitting and after eating. Restless sleep at night, with anxious dreams. Falls asleep late on account of excitability; rush of ideas. Dreamy kind of reverie as soon as he falls asleep. Stertorous respiration in sleep. Sleep restless, unrefreshing.
Coldness at intervals during the day, with cold sweat. Thirst after the coldness; in the evening in bed he cannot get warm. Chill increased after drinking. and yet he is obliged to drink constantly. Heat, with inclination to uncover. Heat continued, even with delirium. Sweat during sleep, all over the body, as soon as it is covered. Sweat after waking at 3 A. M., with thirst; without sweat on feet or head, except where he lies upon cheek. Sweat on the face and hands.
Clinical. Intermittent fever, without constitutional cachexia, except general weakness and anaemia; the paroxysm is fully developed, the three stages of chill, fever and sweat are fully marked; preceding the chill there is violent thirst, often violent temporal headache; there is an interval between the chill and fever, but rarely any gastric disturbance; during the fever there is generally thirst, sometimes unnatural hunger; an interval between the fever and sweat; the sweat is profuse, debilitating, with thirst; during the apyrexia great debility, ringing in the ears, feeling of emptiness in stomach, soreness over the spleen and liver, many symptoms characteristic of the drug.