SOLANINUM. An alkaloid obtained from various Solanums, especially S. dulcamara and S. nigrum, also from the Potato plant, S. tuberosum. C43H69O16. Trituration. Also ***SOLANINUM ACETICUM. C43H69O16C2H4O2. Trituration. Solution.
Clinical
Lungs, paralysis of. Tetanus. Ticklishness.
Characteristics
My first practical acquaintance with *Solan. Was through seeing the excellent effect of *Solan. *acet. 2 in solution given by Dr. Hughes to a diabetic and semi-paralytic man of 60, who had frequent threatenings of respiratory paralysis with accumulations of mucus which he was unable to expel. *Solan. *acet. more than any other remedy rescued him from danger and prolonged his life. From that time I have frequently had occasion to use it in similar conditions. *Solan. is obtained from many of the Solanacea., and especially from *Dulcamara. It exists in potatoes, and under certain conditions of germination potatoes may contain a poisonous amount. An accident of the kind occurred to soldiers at Pfuhl who were supplied with potatoes containing about 24 per cent. of *Solan. (*Medorrhinum *Press, June 5, 1901). Sixty-six soldiers had marked poisoning symptoms: Shivering, fever, vomiting, syncope, and in one case convulsions. Skin and conjunctiva were tinged yellow. *Solan. was proved by Clarus and Schroff and others. Experiments were also made on animals. Slowed and oppressed respiration was a marked feature. Respiration was slowed in inverse proportion to the increase in the pulse rate. There was cerebrospinal irritation, hyperaesthesia and convulsions worse by touch. Skin more easily tickled than usual. In animals the hind limbs were rigid and paralysed, and in the provers the lower limbs were weakened.
Relations
*Compare: Dulcamara, Belladonna, Sol-car., Sol-nig., Sol-tub., Sol-t- aegrotans. (Botan). In respiratory paralysis, Dulcamara, Belladonna Sleepy but cannot sleep, Belladonna Hyperesthesia, Nux vomica, Tetanin.
SYMPTOMS.
Mind
Stupefaction without previous excitement.
Head
Vertigo.-Head: hot, heavy, dull, painful. Pain in occiput. (In rabbits:)-Injection of cerebrospinal passages, especially of medulla oblongata, spasms worse by touch, pendulum-like swinging of head and snapping with the mouth.).
Eyes
Pupils slightly contracted.
Mouth
Salivation.- The pure alkaloid has a cooling, acid, and salt taste, and when chewed causes a glutinous sensation in pharynx and throat, with scraping which extends to stomach, where it becomes a peculiar sticking pain.- Bitter taste.
Throat
Scraping in throat.
Stomach
Constant eructations.-Nausea, and diarrhoea, and vomiting.- Nausea, violent, ineffectual efforts to vomit.-About 5 p.m., vomiting three times without previous nausea, or pain, or any intestinal symptoms.
Abdomen
Rumbling in abdomen.
Urinary Organs
Albumen in urine.
Respiratory Organs
Hoarseness. -Respiration: slow, superficial, difficult, oppressed, distressed, especially on inspiration. -(Decreased frequency of respiration in inverse proportion to increase of pulse. Moist rattle during inspiration.- Frequent violent outcry (from action on medulla oblongata). Masses of mucus in larger air-passages (post mortem).- Paralysis of respiration. (Rabbits poisoned with S.).
Chest.
(Convulsions of muscles of thorax, with which were soon associated tonic spasms of extremities, at first gentle, gradually increasing, and a short time before death suddenly attaining an enormous height, worse by touch. (Rabbits.).
Heart
Pulse: increased in rapidity, weak, thready. – Pulse and respiration slowed. -Increased pulse rate, respiration slowed.- Postmortem, rigidity of heart muscle, all its cavities full of dark, cherry-red coagulated blood. (Rabbits.).
Neck and Back
Cerebrospinal meningitis. (Rabbits.).
Lower Limbs
Slight tonic spasms of lower limbs. Weakness of lower- limbs. (Incapable of moving hinder feet forward.- Hind legs quite stiff, toes stretched out, then great dejection, retching, and signs of pain. (Rabbits, from the *sulphate.)).
Generalities
Weakness.- Sensitiveness to light, noise, and touch.- Convulsions. – Fainting. – (Sudden rapidity and convulsive embarrassment of respiration, general convulsions, tetanic spasms, and strong dilatation of pupil. (Dog.)].
Skin
Skin dry.- Hyperesthesia, creeping along spine when touching the skin, more easily tickled than natural.- Itching.- Yellow discoloration of skin.
Sleep
Frequent yawning.-Great sleepiness with inability to sleep.- Sleep restless, frequently disturbed by frightful dreams. – Sleep frequently interrupted without dreams.
Fever
Extremities cold. -Shivering, fever, vomiting, and syncope.- Profuse perspiration without weakness.
