Homeopathy Papers

Homoeopathic Immunisation Against Leptospirosis in Cuba

Written by Isaac Golden

A groundbreaking study of the successful use of homoeoprophylaxis in Cuba involving millions of people. The target disease, Leptospirosis, is endemic there and the study demonstrated the effectiveness of this safe and low cost method.

Hahnemann first used a homoeopathic potency of Belladonna, selected using the Law of Similars, to prevent Scarlet Fever in 1798. Since then homoeopathic immunisation, or homoeoprophylaxis, has been used by tens of thousands of homoeopaths.

Results have been described in our literature, but there has been relatively little formal statistical analysis of results. Further, most interventions have been by individual practitioners with relatively few people.

This paper provides a graphical description of the use of homoeoprophylaxis by a government’s medical institute to protect literally millions of people. This experience has the potential to change the way homoeoprophylaxis is viewed by parents, practitioners and governments around the world.


The use of homoeoprophylaxis (HP), or homoeopathic immunisation, has been debated in this journal. Some homoeopaths oppose it on philosophical grounds (see the debate between Professor Vithoulkas and Dr Golden), some on more technical/political grounds (see the views of Dr Fisher which have been contested by Dr Golden). However HP has considerable support internationally being, as it is, part of Hahnemann’s “classical” method based squarely on the Law of Similars, and first used by him in 1798.

Irrespective of conceptual issues, the principal question is whether HP is effective and safe. Both aspects have been thoroughly researched and the evidence published. The question of safety is relatively easy given the absence of toxic materials in potentised remedies; however the question of effectiveness and efficacy remains hotly contested by orthodox scientists.

They say that homoeopathy in general is “implausible” because “nothing is there” and therefore both treatment and prevention cannot work irrespective of the evidence. Whilst this is a very unscientific response, it remains the responsibility of advocates of HP to show convincing evidence that it does work.

Due to the recent massive HP interventions in Cuba, we can now offer four main types of evidence to support the effectiveness of both short-term and long-term HP, being:

  1. The historical use of HP from Hahnemann in 1798 to the present day, widely evidenced throughout the homoeopathic literature, and used by many “masters” of homoeopathy
  2. Short-term use of HP in epidemic situations. One of the most thorough of such studies has been by Morinski and colleagues in 1998. A review of such research points to an effectiveness of around 90%.
  3. Long-term use of HP in non-epidemic situations. Golden showed an effectiveness of 90.4% in his research from 1986 to 2004.
  4. The massive and highly successful HP interventions in Cuba involving millions of people from 2007 to 2010.

It is this latter piece of evidence that we will now examine further.

Leptospirosis in Cuba

Leptospirosis is a zoonotic disease which is endemic in Cuba. It usually worsens during the hurricane and high rainfall seasons from October to December each year when the infection is spread via infected water, although rodent urine will also carry the disease.

The three eastern regions of Cuba, Las Tunas, Holguin and Granma (IR = Intervened Region) usually have a much greater incidence of the disease per head of population than the rest of the country (RC) as is clear from Figure 1 which shows the average weekly incidence of leptospirosis for 2003-2006 in IR (2.4 million people) and RC (8.8 million people), weighted per head of population figure for both regions (Average x population in Cuba/population in region).

Figure 1: Leptospirosis, IR and RC, 2003-2006 weekly average weighted per head of population

In both 2007 and 2008 the RC was hit by severe hurricanes. In 2007 the Cuban Government, through the Finlay Institute which manufactures most vaccines used in Cuba, decided to homeopathically immunise the bulk of the population in IR due to a severe spike in the incidence of the disease.

Figure 2 shows the Incidence of the disease in 2007, and the impact of the two-dose HP program which was conducted in Week 45. Once again a weighted per head of population figure is shown, which illustrates the impact of the intervention even more clearly.

2007 was already a worse than average year for residents of IR, and became dramatically so following the hurricanes. However the outbreak “broke” in IR in Week 47, 2 weeks following the HP intervention, although it continued in RC where there was no intervention.

Figure 2: Leptospirosis in IR and RC, 2007, weekly, weighted per head of population

A second two-dose round of HP was administered in 2008 to the residents of IR, this time using a higher potency of the remedy (200C in 2007, 10,000C in 2008 – 2 doses a week apart). Figure 3 shows that the disease remained contained in IR (once again, the most at risk region), but continued as expected in RC apart from a significant single incident in Week 42.

Figure 3: Leptospirosis in IR and RC, 2008, weekly, weighted per head of population

The impact of the HP intervention is clear from the above Figures, but was also demonstrated when comparing the actual progression of the disease in IR in 2007 with the expected number of cases derived using a predictive model based on rainfall experience over time, plus other factors. Figure 4 has been reproduced in other studies of the intervention,,.

Figure 4: Leptospirosis in 2007, actual and predicted incidence

One issue regarding this diagram was the reliability of the predictive model used. Further examination revealed that the model used was quite reliable in IR, but less so in RC.

One final examination of the leptospirosis data from 2004 to 2008 is presented in Figure 5, showing the incidence of the disease for both regions. It shows clearly the seasonal peaks and troughs over the years, with a breaking of the seasonal trend in IR in late 2007, and the substantial reduction of the disease in IR in 2008 despite IR remaining the region most at risk due to severe hurricanes in IR in 2008. It also shows the 2007 prediction for IR shown in Figure 4 (without the HP intervention factored in), but this time shown in monthly figures rather than weekly as in Figure 4.

At this time a predictive trend for 2008 excluding the influence of the HP interventions is not available, but it certainly would show a higher incidence of the disease than that which occurred in RC. However the data which is available clearly shows the positive impact of the interventions. (See Fig. 5 below)

Figure 5: Leptospirosis cases in IR and RC from 2004 to 2008

Concluding Comments

The HP intervention against leptospirosis in IR in 2007 and 2008 has been an unqualified success. The details of the effective intervention were mentioned in the Cuban Assembly. Following on this experience a decision was made to undertake a massive HP immunisation of the total population against Swine Flu in 2009/10 involving over 9.8 million people. The results of this intervention will not be known until 2011 when data can be assembled and analysed.

It is clear that the Cuban initiative in safe, effective, and low cost infectious disease prevention, making the Cubans world leaders in this area of immunisation, will be followed with great interest by both practitioners and public health scientists around the world.

i. George Vithoulkas and Isaac Golden, in hpathy.com, April – September, 2007.
ii. As evidenced in the debate between Dr Fisher and Ben Goldacre. Natural History Museum. http://www.nhm.ac.uk/nature-online/nature-live/video-archive/videos/homeopathic-medicine/
iii. Golden I. A Respectful Challenge to Dr Peter Fisher Regarding Vaccination. J. Hom Med Assn. May, 2009.
iv. Hahnemann S. The Cure and Prevention of Scarlet Fever. Lesser Writings. B.Jain Publishers.
v. Golden I Vaccination & Homoeoprophylaxis? A Review of Risks and Alternatives. 7th edition 2010. Isaac Golden Publications, Cherokee, Victoria, Australia.
vi. For a summary of some major references see Golden I, Homoeoprophylaxis, A Practical and Philosophical Review. Isaac Golden Publications, Cherokee, Victoria, Australia.
vii. Mroninski C, Adriano E, Mattos G. Meningococcinum: Its protective effect against meningococcal disease. Homoeopathic Links Winter, 2001. Vol 14(4); pp. 230-4.
viii.Golden I. Homoeoprophylaxis: A Fifteen year Clinical Study. Isaac Golden Publications, Cherokee, Victoria, Australia. 2004.
ix. Campa C, Bracho G, Cruz R, Menendez J, Martinez R, Gilling E, Wella R. Homoeoprophylaxis: Cuban Experiences on Leptospirosis. Nosodes 2008, International Meeting on Homoeoprophylaxis, Homoeopathic Immunisation and Nosodes Against Epidemics. Havana, Cuba. 10-12h December, 2008.
x. Bracho G, Varela E, Fernández R, Ordaz B, Marzoa N, Menéndez J, García L, Gilling E, Leyva R,Rufín R, de la Torre R, Solis R, Batista N, Borrero R ,Campa C. Massive Application of Highly Diluted Bacteria as Homeoprophylactic Formulation for Leptospirosis Epidemic Control. Homeopathy. 2010. 99, 156-166.
xi. Golden I, Bracho G. The Homoeopathic Prevention of Leptospirosis in Cuba. J.Am. Institute of Homeopathy. Summer. 2010.

Dr Isaac Golden is Business Manager Academic Operations at Endeavour College of Natural Health. He has been in homeopathic practice since 1984, and has conducted the world’s largest long-term trial of homoeoprophylaxis, which formed the basis for his Doctorate in 2004, the first time a mainstream Australian University awarded a PhD in a homeopathic topic. He has authored 10 books on homoeopathy and many articles in Australia and internationally.

Dr Gustavo Bracho is Advisor to the President and General Director of Finlay Institute, Havana, Cuba, and head of the Homeopathy and Biotherapic Projects at the Institute. He is an experienced researcher in molecular and cellular biology, and has headed the Adjuvant Group within the Immunology Department of Finlay. In 2005-2006 he was a researcher in a Collaboration Project with the Flinders Medical Centre, Adelaide, Australia, examining vaccine production methods. He has pioneered the use of homoeoprophylaxis in Cuba as both an adjunct to or an alternative for orthodox vaccination. He is widely published in his area.

Editor’s Note:  Dr. Isaac Golden has been the head of the School of Holistic Medicine at Endeavor College  of Natural Health https://www.endeavour.edu.au/

About the author

Isaac Golden

Dr Isaac Golden Ph.D, D.Hom., N.D., B.Ec(Hon) Deputy Chair and Research Member, National Institute of Integrative Medicine Director, Australasian College of Hahnemannian Homoeopathy. Isaac Golden has been a homoeopathic practitioner since 1984, and teacher since 1988. He founded the Australasian College of Hahnemannian Homoeopathy in 1990. Isaac is a regular contributor to local and international academic journals, and is the author of eleven books on homoeopathy.

He is a world authority on homoeoprophylaxis - the use of homoeopathic medicines for specific infectious disease prevention. He was an Honorary Research Fellow, Faculty of Science, Federation University Australia from 2013 to 2016. He is the Australian contact person for Liga Medicorum Homoeopathica Internationalis. He co-founded the Health Australia Party in July 2015.
Isaac was President of the Victorian branch of the Australian Homoeopathic Association - Australia’s largest national organization of professional homoeopaths - from 1992 to 1998. In March 1999 he was awarded the Association’s Distinguished Service Award.


  • A research paper must include the remedies involved, potency, detailed description of reason for prescription , result, failure inorder to be genuine and it must be useful for other doctors or practicioners. Otherwise it will be a mock attempt.
    yours faithfully

    • Jos – the details you want are in reference ix – there is no need to repeat this detail in every article that follows, especially in the current context.



  • I’m not sure what point JOS is making here but it doesn’t seem constructive. I would have expected the whole world to sit up and take notice of this report from Cuba — not to blindly say, “Right, homeopathy works” but at least, “That’s interesting, maybe there’s something in it after all, let’s do more research and let’s carry out some similar projects on infectious disease.” Except that sadly, that’s not how things go. Instead we find excuses to ignore this seminal project.

  • Dear Doctor Isaac,
    Would you please tell about the
    a. name and potency of the remedy used for vaccination
    b. number of people vaccinated
    c. number of people not vaccinated(control group)
    d. number of people who had the disease out of the vaccinated group and in the second group. The attack rates in both the groups
    e. number of people having side effects of vaccine and the type of reactions

    [email protected]

    • Dear Dr saif

      No one was vaccinated homoeopathically – we don’t vaccinate – however there were around 2.4 mill in 2007 and 2.2 mill in 2008 who were homoeopathically immunised I don’t wan to sound pedantic, but it is important that we use the correct language which means we correct principles are understood – vaccination and homoeoprophylaxis are totally different methods of ahieving protection against a targeted diseasze)(c- the remedy details etc are shown in reference ix, which is the source artilce relating to the homoeopathic intervention.

      best wishes


  • Well done with all this work. A couple of thoughts
    1. Have you any evidence of how those people that contracted the disease in the IR area fared compared to a non HP vaccinated case. i.e. did they respond to treatment better than others?
    2. Were those that contracted the disease treated homeopathically and what observations were made?
    3. What long term health problems followed those that had HP? i.e. are the HP non infected group left with a “lesser” condition?
    4. The trial used the vaccine. Were there any better simillimums rather than the tautopathic remedy?
    5. Would be very interested to see if giving the 200 potency daily throughout the month would dramatically improve the outcome. This repetition of dose is something I have found is useful where there is a strong maintaining cause that cannot be addressed.

    • Interesting points Len – and appropriate ones – I don’t have the answers and am not sure this detaiul was kept. Br Bracho would be the one to respond to this.

      It is clear from some of the other comments that some readers thought this wasa trial. It was not. It was a practical intervention in a critical situation to save lives – not some constructed test to prove a point. Thus not every statistic could be covered.

      Going forward the opportunity to collect greater data and develop more details may well be available.

      Re your final point re 200 daily – I personally have found that a dose ranging from fortnightly to at the very most twice weeekly was plenty to provide protection when exposure was continuous. I would have concerns giving 200 daily for a month as the chance of developing proving symptoms would increase greatly

      thanks for your input


  • Dear sir
    Is the nosode for leptospirosis available? What is the name of nosode? In what potency is it effective?

    • Dear Dr Gaitonde – the details of the remdy used are in reference ix – the remedy was produced by the Finlay Institute in Cuba who, to my knowledge, would be the best place to source the remedy



  • All this is interesting but if we do not know the remedies chosen and the way followed in the prophylaxis, where is the interest for a homeopathic doctor

    • Hi Anne – this thread has been inactive for 2 years – not totally sure what you mean by later studies – but I am not aware that data has been processed for lepto after 2008 – although I am hoping that it will be early next year – Dr Bracho has been working to collect data for the next analysis. I hope this is what you mean

  • From Figure 1, it appears that the incidence of Leptospirosis in Cuba drops from an annual maximum in the last week of December to zero in the first week in January. It just vanishes. Either New Year’s Eve cures it, or there is something else going on here. Is it possible that reports of Leptospirosis reach a peak around Christmas because some people use it as an excuse to have a holiday at that special time of the year? Of course, only the treatment group would know that their health was being monitored during December. Any nearby area where the population was not visited and given a “vaccination” would probably not experience a reduction in fake leptospirosis claims. They would carry on as usual and would be useless as a control group.

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