Dr Awanesh Kumar1, Dr. Nandeshwar PD Singh2 ,Ashutosh Kumar 3, Varsha Rani4
This idea was derived from data on cancer sufferers over 20 years of our medical practice. We carefully collected present condition, past history and genetic counseling data of the cancer patients. Different types of 130 case histories of cancer patients indicated similar manifestations, which are functional, morbid, changing, degenerative changes or outgrowths, ie. inside or outside of the body. Sudden occurrence of cancer was not found until now. There was a long history of illness and medical treatments of the patients and their past generations. A set of chronic diseases are found in their past history and also familiar traits.
There are many difficulties in the study of human genetics and we will discuss briefly family studies that can be used to find the genetic basis of human traits in the course of the carcinogenesis. This involves pedigree analysis, where the phenotypic / symptomatological records of families extending over several generations are compiled. On this basis, we hypothesized the segregation pattern. Naturally the more complex the pedigree, the more accurate the genetic analysis The pedigree analysis is the study of traits as they have appeared in the given family line for several past generations i.e. maternal and paternal traits. Past and present symptoms of the patients are also compiled.
In order to determine the mode of inheritance of a trait, it is usually necessary to analyze the data from family histories. Retrospective family studies usually start with an affected individual and work outward from him, through the existing family. One problem with this approach may be the inability to obtain relevant data on deceased relatives or others who are not readily available. Pedigree analysis and patients’ histories indicate mainly two sets of chronic diseases, i.e. psora and sycosis, which meet together. Rarely syphilitic traits are also mixed together. We found in most cases that the hereditary constitution of the individual plays an important role in the cancer origination. It can be seen in the following figure –
Psora X Sycotic Derived from past history of the patients and their pedigree–analysis of maternal & paternal traits.
Carcinogenesis – Sensitive to carcinogenesis.
Here, we see the hereditary factors viz psora & sycosis are the main genetic (miasmatic) causes of cancer. It also provides sensitivity to carcinogens in the individuals, and plays an important role in the disease. The course of disease will depend on the genotype of the individual, carcinogenic agent and who comes in contact with it.
The study of human genetics is studied considering the fact that unlike other species of animals and plants, humans cannot be bred experimentally. Therefore we cannot apply the genetic analyses that have been used by Mendel and Devries etc.
This is because:
(a) Not able to arrange the different (wanting) mating.
(b) Long life cycle and relatively less production of offspring
(c) Humans do not live in a uniform environment or uniform conditions.
Therefore genetic counseling and pedigree analysis are basically the source of information about the human genetics. This paper described some aspects of cancer origin, which are hidden truths and have not been described yet. The cancer risk factors of human traits are studied by the case history of present and past illnesses and their genetic counseling and pedigree analysis. The tools for evaluating factors in cancer origin involve hereditary constitution and may be divided into several categories.
Sensibility of the constitution and morbid agents produce changes in the phenotype of human traits in different ways, such as functional, degenerative and non- degenerative changes. There is a high risk of carcinogenesis, where psora and sycosis are found in the past history of maternal and paternal traits. This is the genetic (miasmatic) cause of cancer. Carcinogens are the maintaining and exclusive cause (causa-occasionalis) of cancer. If both causes (psora &sycosis) meet in a particular platform, then the greater the probability of cancer growth.
Objectives of the Study
Cancer is not a single disease, but an array of different disease, all characterized by uncontrolled cell division .Cancer is a dreadful disease and its incidence is always increasing. There has been no absolute preventive nor curative treatment. Once the fundamental cause of carcinogenesis is established, many doors will open for further activities in this area. Pedigree analysis of the cancer patient has not been well collected by previous workers. We studied the back generations of the patients, then drew a guideline for genetic origination. The available information becomes a valuable tool for arresting, minimizing, preventing and treating the different dimensions of cancer.
Methods & Materials
The methodology is completely based on findings of case histories of different types of cancer patients of both sexes and different age groups, locations, cultures, habits, races, skills and modes of living. All these cases are fully diagnosed from recognized medical institutions, laboratories and hospitals i.e. haematology, serology, ultrasonography, FNAC, biopsy and so on. It is notable that the present clinical study of cancer was undertaken and fully based on case histories of the present and past illness and their maternal and paternal traits of diseases with as much detail as possible. We retrospectively analysed the files of patients diagnosed with cancer for 20 years of our practice and included also genetic counseling and pedigree analysis.
In the present clinical study, the total number of patients enrolled was 130, however 30 case histories were only partially collected in our early working period, because this new idea was not fully developed. After some data collection of the case histories and evaluating the facts, the methods needed became more clear to me. This can be seen easily in the summaries of case histories. The primary purpose of this paper is to find the “fundamental cause of the origin of cancer”.
Even when in contact with carcinogens, some people are resistant to cancer. Thus these agents are only exciting causes and this fact also indicate that some genetic causes are also present.
Total races, age groups and sex of the case histories are indicated in the table below:
Table No – 1.
Total No of patients ——————————————————130
Total No of male ———————————————————–60
Total No of Female ——————————————————–70
Total No of Hindu———————————————————117
Total No of Muslim —————————————————— 13
Total No of Hindu male — ————————————————53
Total No of Hindu Female ————————————————64
Total No of Muslim male ————————————————–07
Total No of Muslim female ———————————————–06
Total No of Children — —————————————————-03
Total No of Adult ——————————————————- 127
Total No of Others. ——————————————————–00
All diseases are classified under Psora, Syphilis &Sycosis, as indicated in key words. Based on case histories of present and past illnesses, genetic counseling and pedigree analysis, we arrive at table No -2.
Table No – 2.
Types of cancer to be observed in this table
- Liver Cancer —————————————————————— 40.
- Lung Cancer ——————————————————————- 03.
3.Mouth Cancer —————————————————————— 12.
- Gland Cancer Including (Lymphoma) ———————————— 11.
- Blood Cancer – Including (Leukemia) ————————————– 07.
- G B Cancer ——————————————————————– 06.
- Uterine Cancer —————————————————————— 06.
- Cervical Cancer —————————————————————– 08.
- Prostate Cancer – —————————————————————– 01.
- Chest Cancer – —————————————————————— 03.
- Throat Cancer – —————————————————————— 06.
- Pancreatic Cancer – ————————————————————– 02.
- Ovary Cancer – ——————————————————————- 01.
- Lip Cancer – ———————————————————————- 01.
- Knee Cancer – ——————————————————————– 01.
- Gastric Cancer— —————————————————————– 03.
- Abdomen cancer – ————————————————————— 01.
- Colon Cancer – ——————————————————————– 02.
- Breast Cancer – ——————————————————————– 07.
- Glioma – —————————————————————————— 02.
- Cervical Cancer – —————————————————————– 01.
- Skin Cancer – ———————————————————————- 01.
- Stomach Cancer – —————————————————————– 02.
- Anal Cancer – ———————————————————————– 01.
- Necrosis —————————————————————————— 01.
- Glioblastoma ————————————————————————- 01.
The beginning data is less detailed. Gradually, due to advancements in our knowledge, the data becomes more complex. In the primary stage only simple case histories of the patients were collected. Afterward we found previously taken case histories were not sufficient. Later on, more detailed case histories were taken.
Table No- 3.
Page of table 2 Total pt’s Past history Maternal traits Paternal traits Remarks
– – Psora syph syco psora syph syco psora syph Syco
- 14. 11 01 06 02 00 01 02 00 01
02 21 15 01 11 07 00 05 08 00 05
03 20 16 02 09 04 00 04 16 06 12
04 22 14 02 04 06 03 04 14 00 01
05 24 13 02 07 08 02 05 12 00 07
06 24 11 04 12 12 00 10 17 00 16
07 05 04 00 03 05 00 02 04 01 03
GT 130 84 12 52 41 05 31 73 07 45
% 130 64.62 9.23 40.00 31.53 3.84 23.84 56.15 5.38 34.61
Result : Data based on present and past case histories of patients and their maternal and paternal pedigree analysis are shown in the following table.
Table No – 4.
Particulars drawn from: Psora % Syph % Syco % Remarks
Past History 84 64.62% 12 9.23% 52 40%
Maternal pedigree analysis 41 31.53% 05 3.84% 31 23.84%
Paternal pedigree analysis 73 56.15% 07 5.38% 45 34.61%
Now we observed each pedigree of the patient’s past history, maternal and paternal traits and found the following: