Scientific Research

An Endeavor to Illustrate an Objective Evidence for the Action of Homeopathic Medicines by Measuring Physiological Variability in Human Body Temperature

Homeopathic medicines of 200C potency are applied orally to human subjects. ‘Physiological variability in temperature’ from skin of forearm is measured with the help of temperature data logger and water/soil temperature sensor. Temperature readings are taken at an interval of 1 second for 5 minutes. Time series spectral analysis is performed by using Statistical processing software. The statistical procedures like Auto Regressive Spectrum (ARS) and Parametric prediction and reconstruction (PPR) are used to study the change in temperature variability. There is marked change in temperature variability before and after applied homeopathic medicine.

Key words: Homeopathic medicine, Physiological variability in temperature, temperature data logger, water/soil sensor, AR Spectrum, Parametric Reconstruction and prediction

Aims and objectives:

Primary:

1.      To show an objective evidence for the
action of Homeopathic medicine by measuring physiological variability
in human body temperature.

Secondary:

1.      To draw signature for individual Homeopathic
medicines.

2.      To find out a unified method to select
homeopathic medicine for diseased individuals.

3.      To introduce objective measures into Homeopathic
system of medicine like data loggers and sensors to measure physiological
variability for selection of Homeopathic medicine.

Introduction and review:

Homeopathy is a well-described, scientifically based system of approaching
health and disease. "Scientific" because the insights
are based on reproducible experiments. "Well-described"
because from these observations a number of precise basic fundamental
rules became evident, first among them the "similarity principle.12
"But lack of objective evidence for the action of Homeopathic
medicine bestow an opportunity for skeptics to comment ridiculously.

Although homeopathy is only 200 years old, it is now practiced in a variety
of ways, most of which bear little resemblance to what Hahnemann
taught. In the public mind the word "homeopathy" has
become so vague that for some it means only an "alternative
medicine" and for others a combination of homeopathic medicines
that you buy in the health food store, one mixture for allergies,
another for headache, etc12. There by it needs a unified
method to select similar homeopathic medicine for a patient’s
disturbed energy field.

Our earth by virtue of a hidden invisible energy, carries the moon
around her in twenty eight days and several hours, and the moon
alternately, in definite fixed hours (deducting certain differences
which occur with the full and new moon) raises our northern seas
to flood tide and again correspondingly lowers them to ebb.3

According to the homeopathic way of thinking, a disease originates from
a disturbance of the patient’s "vital force." This is
the life force energy that sustains life. As the origin of disease
occurs on this energetic level, the homeopathic remedy has also
to be on this level.12 The current study provides objective
evidence for the action of homeopathic medicine and also deals
with identification of similar homeopathic medicine for the patient’s
disturbed life force by means of objective measures, “Data loggers
and Sensors”.

This study facilitates in the drawing signatures for individual Homeopathic
medicines. This study also gives you an idea about approach, to
develop a common method to select accurate Homeopathic medicine
for diseased individuals.

In order to recognize the behavior of homeopathic medicines, which
are applied orally, it is attempted to study the natural regulatory
mechanisms in the Human body as well as in nature.

In this regard Biorhythms, “occurrence of cyclical biological events”,
have supported the hypothesis that “Homeopathic medicines produce
cyclical change in the human body”.  Extension of this initiative
guide to the study of the function of the Hypothalamus “the seat
of biorhythms”.

The hypothalamus is responsible for certain metabolic processes and other
activities of the Autonomic Nervous System. It synthesizes and
secretes neuro-hormones, often called hypothalamic-releasing hormones,
and these in turn stimulate or inhibit the secretion of pituitary
hormones. The hypothalamus controls body temperature, hunger,
thirst, fatigue, and circadian cycles
.9

The tiny dose of Homoeopathic Medicines to some extent
move up the thermoregulatory set point located in the Hypothalamus
of living beings naturally required for the rise in body temperature
in order to deactivate the microbes (Disease Forces).13

The effects of tiny doses of Homoeopathic Medicines simulate the Biologic
Activities of Pyrogenic Cytokines like IL-1, TNFa, AND IL-6 and
INFs. The potentised dose of similar Homeopathic Medicines (just
like PGE2) is the most potent of fever-producing means, without
inflicting any injurious effect to the sick living being when
prescribed on symptom similarity and in infinitesimal low doses.13

So one of the regulatory functions of the Hypothalamus, ‘Thermoregulation
in human subjects’ is taken as the primary subject to understand
the action of Homeopathic medicine. The parameter “Physiological
variability in human body temperature
” (Vital Heat) is selected
for the study.

The history of the study of variations in the physiological parameters
goes back to 18th century, when Stephen Holes documented
beat to beat variability. He related spontaneous fluctuations
in the peripheral blood flow to adjustment in the continuous circulation
by the thermoregulatory system.2

Thermoregulation is the ability of an organism to keep its body temperature
within certain boundaries, even when the surrounding temperature
is very different. This process is one aspect of homeostasis:
a dynamic state of stability between an animal’s internal environment
and its external environment.10

The organism that thermoregulates is one that keeps its core body
temperature within certain limits. It was not until the introduction
of thermometers that any exact data on the temperature of animals
could be obtained. It was then found that local differences were
present, since heat production and heat loss vary considerably
in different parts of the body, although the circulation of the
blood tends to bring about a mean temperature of the internal
parts. Hence it is important to identify the parts of the body
that most closely reflect the temperature of the internal organs.
Also, for such results to be comparable, the measurements must
be conducted under comparable conditions. The rectum has traditionally
been considered to reflect most accurately the temperature of
internal parts, or in some cases of sex or species, the vagina,
uterus or bladder. Occasionally the temperature of the urine as
it leaves the urethra may be of use. More usually the temperature
is taken in the mouth, axilla, ear or groin.10

The body owns a regulatory system that keeps body temperature within a
close range. The centers of this system are located in the hypothalamus.
Temperature sensors are found in the preoptic and anterior hypothalamic
nuclei. More sensors are contained in the skin and in a
few deep tissues in the body. The temperature is regulated by
a nervous feedback mechanism. The signals from the sensors are
evaluated in the posterior hypothalamus.5

In this study, temperature is measured from the skin of the forearm.  As
this study doesn’t require exact values, the variability in temperature
is measured from skin. “It is supposed that Homeopathic medicines
produce change in temperature variability”.

Materials and methods:

1. Equipment:

A.      Temperature Data logger,

B.     Water/Soil Temperature Sensors ,

C.     PC & Green line data logging software.

D.     Human Subjects.

E.     Homeopathic Medicines of 200C Dilution.

F.      Statistical Processing Software for Data
Analysis.

2. Temperature Datalogger Specifications:

         i.           
Measurement range: -40  to 1580 F

       ii.           
Accuracy: + or – 0.63 0F ( from 320  to
1220 F)

      iii.           
Resolution : 0.050 F at 770 F

     iv.           
Response time in airflow of 1 m/s :  6 minutes

       v.           
Operating temperature: -40  to 1580 F(logging),
320  to 1220 F(Launching/Readout)

     vi.           
Memory: 64 bytes

    vii.           
Weight: 46g(1.6 oz)

3. Water/Soil Temperature Sensor Specifications:

         i.           
Measurement range: -400 to 1220 F
in water, -400 to 2120 F in air.

       ii.           
Accuracy: + or – 0.450 at 650 F

      iii.           
Resolution: 0.050 F at 680 F

     iv.           
Response time in airflow of 1 m/s:  3 minutes, 30 seconds in water.

       v.           
Operating range: sensor tip and cable immersion in fresh water
up to +1220 F.

     vi.           
Material: Housing stainless steel sensor tip.

    vii.           
Probe dimensions: 0.5cm X 2.5cm



4. Methodology:

The experiment was conducted with Human subjects. Freshly medicated 6-9
Homeopathic pills were applied orally half an hour prior to the
acquired temperature readings. Temperature readings were obtained
from the skin of the forearm of the subjects. A water soil sensor
was connected to the skin by means of cellophane tape. Readings
were taken in the sitting posture. Subjects were instructed not
to move while obtaining readings. Method of connecting data logger
and sensor was shown in Fig 2.

Temperature readings were taken at an interval of 1 second for 5 minutes.
Each data file of a subject contains 300 readings. After obtained
readings, data can be exported to an excel file. Each data file
contains 300 temperature reading points i.e. Temperature variability
data
.



5.      Protocol:

Two types of protocols are followed in these experiments.

    5.1. With Placebo control: Subjects are divided into the medicine
group and the placebo group. Homeopathic medicine is applied
to one group and placebo to another group. E.g.: Exp No:1, Exp
No:2, Exp no:6, & Exp no:7.

    5.2. Without Placebo control: Subjects are not divided
into groups.  Reading are taken from the same subjects before
and after applied homeopathic medicine. E,g,: Exp No 3, Exp
No:4, Exp no:5, Exp no:8 & Exp No:9.

6. Statistical Analysis:

The temperature variability data is processed with statistical processing
software. The statistical procedures Auto regressive spectrum
(AR Spectrum) and Parametric Reconstruction and Prediction
(PRP) are used for the data analysis. With these procedures
the time series data can be converted into frequency domain
data.

In statistical signal processing and physics, the spectral density,
power spectral density (PSD), or energy spectral
density
(ESD), is a positive real function of a frequency
variable associated with a stationary stochastic process, or
a deterministic function of time, which has dimensions of power
per Hz, or energy per Hz. It is often called simply the spectrum
of the signal. Intuitively, the spectral density captures the
frequency content of a stochastic process and helps identify
periodicities.14

In physics, the signal is usually a wave, such as an electromagnetic wave,
random vibration, or an acoustic wave. The spectral density
of the wave, when multiplied by an appropriate factor, will
give the power carried by the wave, per unit frequency, known
as the power spectral density (PSD) of the signal. Power
spectral density is commonly expressed in watts per hertz (W/Hz)
or dBm/Hz.14

For voltage signals, it is customary to use units of V2Hz−1
for PSD, and V2sHz−1 for ESD or
dBμV/Hz.14

For random vibration analysis, units of g2Hz−1
are sometimes used for acceleration spectral density.14

6.1 Autoregressive model:

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Devendra Kumar Munta

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