Scientific Research

Heterotopic Ossification in a 7‐Year‐Old Female Patient Treated with Individualized Homeopathy: A Case Report

The authors present a case of a 7‐year‐old female patient suffering from severe congenital heterotopic ossification, and treated successfully with individualized homeopathy.

First published: 19 November 2019

Open Access


Classical homeopathy can be included among the treatment options for congenital heterotopic ossification.


We present a case report of a seven‐year‐old girl suffering from severe congenital heterotopic ossification. The patient received treatment with individualized remedies according to the rules of Classical Homeopathy, demonstrating steady improvement in both her clinical condition and the radiological findings over the next 2 years.

Heterotopic ossification (HO) consists of the formation of bone tissue at extraskeletal anatomical sites at the expense of local tissues, including muscle and connective tissue.1 The formation of lamellar bone in soft tissues, where bone normally does not exist, is also called myositis ossificans. However, it would be more accurate to describe the involvement of skeletal muscles as myositis ossificans and the involvement of soft tissues in general as ectopic or heterotopic ossification.2 These bony masses can lead to chronic pain, joint ankylosis, pressure ulcers, venous thrombosis, and many other health complications.3

Heterotopic ossification can be acquired, triggered by trauma, surgical procedures, spinal cord and brain injuries, extensive burns or long‐lasting immobilization.12 Congenital HO is a very rare condition that occurs in pediatric patients and is regarded as an autosomal dominant disease with irregular penetrance leading to ectopic bone formation and motion disturbances.4Morbidity and early mortality in children is due to respiratory complications and improper treatment of the lesions, with very few cases being cured by surgical intervention.56


The patient of our case report is a 7.5‐year‐old girl who presented to the clinic with extensive clinical and radiological signs of heterotopic ossification. Five years ago, when the patient was 2.5 years old, the first radiological investigation showed extensive soft tissue calcification, with normal alignment and architecture of the bones and no evidence of fracture, lytic or sclerotic bone lesion (Figure 1). A skin biopsy from the lesions of both thighs showed the possible diagnosis of “calcinosis cutis.” At that time, the antinuclear antibodies (ANA) were positive and lactate dehydrogenase (LDH) was elevated (346 IU/L, normal range 81‐234 IU/L), indicating tissue damage. SGPT was 44.4 IU/L (normal 0‐31), SGOT was 43.5 IU/L (normal 0‐31), and ALP was 163 IU/L (normal 28‐78). Juvenile dermatomyositis was the diagnosis given after a dermatologic consultation, and the patient was prescribed topical corticosteroid ointments and oral methotrexate. There was no improvement in the clinical condition of the patient, so she discontinued the treatment 4 months later.

Figure 1

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The first radiological findings, patient 2 y old

On clinical examination, the patient suffered from obvious hard bony nodules on the face and both upper and lower limbs, which initially appeared at the age of 2.5 years. Those nodules were painful, especially during the night, with one or two new nodules appearing every month; the nodules discharged from time to time, leaving deep scars. Because of the nodules, the patient could not extend her right elbow and could not squat (Figure 2). She was a timid and reserved girl, with no relevant family history and her personal medical history was clear from any other major disease. Very interestingly when writing, she would make habitual mistakes, writing mirror images of the letters and numbers (Figure 3).

Figure 2

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Clinical condition of the patient on first consultation

Figure 3

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Writing pattern of the patient

2.1 Treatment/Outcome

The patient was treated with individualized remedies according to the principles of classical homeopathy and attended regular follow‐up visits. Table 1 presents the symptoms and the homeopathic remedies given to the patients over the course of her treatment. After the first month, her clinical picture was definitely improved: There were no more night pains, and the child was more active. There was no occurrence of any new nodes, and two old nodes became soft and discharged a lime‐colored discharge from the skin (Figure 4). Treatment with a series of remedies (Table 1), which were all prescribed according to the rules of classical homeopathy, continued over the following months, with slow but steady improvement of the condition of the patient. Seven months after the initial treatment, a calcific deposit was literally expelled from her left arm (Figure 5).

Table 1. Series of remedies prescribed to the patient during the course of her treatment

Date Symptoms Prescription
19 April 2017 Painful calcific nodes—symptoms worse during nighttime and from slight touch and motion. Offensive stools, urine, and breath odor. Reserved girl, making mistakes during writing, transposing letters. Desires salt and butter, dislikes sweets Mercurius solubilis, 1 mol/L, one dose
20 May 2017 No night pains, gained 300 gr, more active. No new nodes. Two old nodes became soft and discharged lime‐like discharge No remedy prescribed
21 August 2017 Desires sweet, weeping—tearful mood, timid when appearing in public. Offensive smell of stool with constipation. Dictatorial attitude. Still makes mistakes when writing, transposing letters Lycopodium, 1 mol/L, one dose
10 February 2018 Patient continues to make mistakes in writing, lack of confidence, does not want to go to school Repeat lycopodium 1 mol/L, one dose
23 September 2018 Nodules softened, as if ready to ooze—two of them red and very painful from slightest touch. Child cries because of pain. Hot head with cold extremities Belladonna, 1 mol/L, one dose
19 December 2018 Offensive body discharges (stool, urine, perspiration), itching of the nodules, eats nasal crusts, disordered, desires sweets Sulfur, 1 mol/L, one dose

Figure 4

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Discharging node of the right hip and knee 1 wk after first remedy

Figure 5

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Calcific deposit expelled from left arm, 7 mo after initial treatment

The radiological investigation 15 months after the initial treatment showed a significant reduction in the number and size of the calcific opacities (Figure 6). The patient could now squat and extend her right elbow joint. The radiological improvement was evident until the follow‐up visit and 23 months after the initial visit (Figure 7). The clinical condition of the patient was improving, and the laboratory studies were better: LDH 294.9 U/L (normal: 135‐214 U/L). The patient has not developed any new nodes since the beginning of the homeopathic treatment; actually we did not observe any new node after the first remedy. Additionally, we noticed improvement of her writing pattern; in the last follow‐up visit, the patient was not making any mistakes in writing at all.

Figure 6

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X‐rays of both legs and from right arm in the beginning of treatment and 15 mo later

Figure 7

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X‐rays, 23 mo after initial treatment

The latest X‐rays of the patient were taken 29 months after the initial treatment (Figure 8). According to the Radiologist’s report, “There is significant regression of soft tissue calcification in limbs as compared to previous films – No new lesion has appeared.”

Figure 8

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The latest X‐rays, 29 mo after initial treatment


Homeopathy, the “energy medicine,” founded in the nineteenth century by Dr Samuel Hahnemann (1755‐1843), is a branch of medical science based on the principle that diseases can be cured by strengthening the body’s defense mechanism with substances selected for their energy‐giving properties. This observation is known as the law of similars (Similia Similibus Curantur). Derived from the Greek words “homeo” and “pathos”, meaning “similar suffering,” homeopathy uses remedies, selected from herbs, minerals, or chemicals, which, in their crude form, would produce in a healthy body the same symptoms found in a sick person suffering from the specific disease. However, this crude substance is diluted and purified beyond the point of harm to its quintessential state of energy.7

The entire issue concerning health and disease hinges on the organism’s ability to maintain homeostasis. The energy complex—also known as the “vital force,” according to Hahnemann8—is connected to the defense mechanism as a whole, being the foundation for optimal health and wellness, or lack thereof. When the energy complex is affected, imbalance of the organism is created. In time, this disparity has a great impact on the physical organism, causing disease.9

The extreme dilutions used in homeopathic remedies—dilutions beyond Avogadro’s limit (<1023) and the assumption that substances diluted to that degree cannot contain active ingredient—have been the subject of heated controversy since Hahnemann’s time, leading to the argument that homeopathic remedies contain no active ingredient and are, therefore, inert. Nevertheless, recent research proves the opposite. Chickramane et al (2010) were the first to discover the presence of nanoparticle source materials of metal‐derived homeopathic medicines in multiple ultradilutions beyond Avogadro’s number by using transmission electron microscopy (TEM), electron diffraction, and chemical analysis by inductively coupled plasma‐atomic emission spectroscopy (ICP‐IES).10Even more recently, Tournier and Roberts in 2015 experimented with solvatochromic dyes and showed that the presence of homeopathic dilution glycerol 50 mol/L consistently and reproducibly affected the absorption spectra of all six solvatochromic dyes tested when compared to the control, meaning that homeopathic dilutions are not “just water” 1113 !

The pathogenesis of acquired HO is not clear, but it is thought that severe local inflammation triggered by the physical insult leads to the recruitment of progenitor cells, the release of proskeletogenic factors, the derangement of the normal tissue repair processes, and, finally, the formation of heterotopic bone.1However, congenital HO is very rare, but can be very severe, occurring in children with fibrodysplasia ossificans progressiva (FOP) or progressive osseous heteroplasia (POH). Several mutations in these pathological conditions have been identified, and they all cluster in the intracellular glycine‐serine (GS)‐rich domain of ALK2, the most common of these mutations being the ACVR1R206H14.

Congenital HO could be truly difficult to treat. In FOP patients, the pathology can be very aggressive, involving the accumulation of large amounts of endochondral bone masses throughout the body. HO in those patients is inoperable, since the disease is highly reactive and surgery could cause recurrent and even more severe HO. During the exacerbations of the symptoms, high doses of corticosteroids for a brief period of 4‐5 days are indicated. Steroid treatment can alleviate inflammation, swelling, and pain, but cannot reduce the progression of HO.15 Since FOP patients carry mildly activating mutations, therapeutic strategies, over the last few years, have been experimenting with various drugs directed toward specific paths in the pathogenic cascade of the disease.1

Both the clinical and the radiological results of our patient after her treatment with individualized classical homeopathy are definitely promising. According to Vithoulkas, the defense mechanism as a whole appears to have a “higher” intelligence that is able to maintain optimum balance under any stress. Homeopathy can treat diseases with milder means, which promote and enhance the natural reaction of the immune system.1618


We present a case of a young girl suffering from extensive congenital heterotopic ossification whose treatment according to the principles of classical homeopathy had very good clinical and radiological results. This is the first published case concerning the treatment of this difficult pathology with classical homeopathy. Many more cases and much more research are definitely needed in order to conclude that classical homeopathy can be a treatment option for this severe pathology.


The authors have no conflict of interest to declare.


Dr JA and Dr LJ: were responsible for the treatment of the patient, under the supervision of Prof. GV. Dr SM and Dr DT: underwent the literature review and the writing of the paper.


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About the author

Seema Mahesh

Dr Seema Mahesh (BHMS, MD (hom) Dip IACH (Greece), MSc Medical Sciences (Malaysia) is a classical homeopath from Bangalore, India, practicing for the past 20 years. She completed homeopathic medical education at the Rajiv Gandhi University and her PG diploma at the International Academy of Classical Homeopathy (IACH), Greece, under Prof George Vithoulkas. She then turned to research and trained at the Taylor’s University Malaysia for her research post-graduation degree in Medical Sciences. She has been involved in the research committee of IACH and is currently the Director of Research at IACH Greece, collaborating with clinicians and researchers from 95 countries. She is instrumental in taking the core concepts of classical homeopathy to the medical journals and conferences. Having published 22 research papers in peer reviewed medical journals, and hundreds of articles on other platforms, she has also presented her research on concepts of health, disease and cure at medical conferences of immunology and autoimmunity, at NewYork USA, Fiji, Dublin Ireland, Krakow Poland, Stockholm Sweden, Harvard Medical School USA, Amsterdam Netherlands, London UK, Madrid Spain,Vancouver Canada, Tel Aviv Israel, Istanbul Turkey, New Delhi, Athens Greece, Basel, Switzerland and Paris, France. Her presentation at Harvard won her an award of excellence. Her research papers have been downloaded a record number of times.

About the author

Atul Jaggi

Dr. Atul Jaggi is Director of H3 - Health & Happiness by Homeopathy, Centre of Classical Homeopathy, Nashik, Maharashtra, India. Dr. Jaggi came in contact with Homeopathy in 1991 when he started studying from one of India’s best college – Nehru Homeopathic Medical College and Hospital, New Delhi. But his real homeopathic evolution began, when in 1996 he got fortunate to join the first group of Four Year Course in International Academy of Classical Homeopathy (IACH), headed by Prof George Vithoulkas. In 2000, he received the esteemed Diploma of IACH and was awarded with a scholarship, as he stood 3rd amongst 170 International doctors. Since 2016, he is a teaching member at IACH, Greece and he also gives International seminars and Webinars. His main mission is to bring students in contact with the precious and life changing teachings of Prof George Vithoulkas and spread real Hahnemannian Classical Homeopathy.

About the author

George Vithoulkas

George Vithoulkas is an Honorary Professor of the Moscow Medical Academy, Professor in the Kiev Medical Academy, Honorary Professor at the University of the Aegean, Greece, Collaborating Professor in Basque Medical University (2001-2004) and Doctor Honoris Causa of "Doctor ViktorBabes" University of Medicine and Pharmacy of Timisoara in Romania. In 1995, he established International Academy of Classical Homeopathy in Alonissos, of which he is the director. In 1996, he was honored with the Right Livelihood Award (also known as Alternative Nobel Prize) "for his outstanding contribution to the revival of homeopathic knowledge and the training of homeopaths to the highest standards".

About the author

Latika Jaggi

Dr Latika Jaggi is Director of H3 - Health & Happiness by Homeopathy, Centre of Classical Homeopathy, Nashik, Maharashtra, India. She completed her homeopathic graduation in 1998 from one of India’s best colleges – Nehru Homeopathic Medical College and Hospital, New Delhi. She passed the highly esteemed Diploma of IACH and for the last 25 years she has regularly attended seminars of International Academy of Classical Homeopathy (IACH), Alonissos, Greece to spread the flame of Classical Homeopathy. Together with Dr Atul Jaggi, she has moderated the E-learning Course of IACH in Maharashtra, India since 2013. In 2019, she was appointed by IACH as the E-learning Moderator for English speaking students and she continues the same with great enthusiasm to this day. She has also been presenting the in-depth educational lectures of Prof. George Vithoulkas in International seminars and Webinars, since 2016. Dr. Jaggi and her husband share the mission to bring students in contact with the precious and life changing teachings of Prof George Vithoulkas.

About the author


Orthopaedic Surgeon, Rehabilitation Centre General Hospital of Aitoloakarnania, Agrinio, Greece

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