Summaries of Some Recent Research in Homeopathy

Last modified on January 17th, 2015

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We present summaries of some recent research in homeopathy. The first one will be interesting to anyone who uses water/alcohol potencies.

1Institute for Scientific Homeopathy, Kaiserstr. 28, 63065, Offenbach, Germany,

dr.karin.lenger@t-online.de

Cell Biochem Biophys. 2014 Mar;68(2):321-34. doi: 10.1007/s12013-013-9712-7.

Identification of unknown homeopathic remedies by delayed luminescence.

Lenger K1, Bajpai RP, Spielmann M.

Author information

Abstract

A quality control method of highly diluted and potentized homeopathic remedies is important for curing patients applying homeopathic therapy. Lenger detected photons in highly potentized homeopathic remedies by delayed luminescence. The photons of Argentum metallicum 100MK and Cantharis 100MK magnetically bound to their carrier substances ethanol or saccharose were separated by their resonating magnetic field of about 2.06 MHz. The photons of these 100MK potency levels and of their reference substances were determined to be standard values calculated by the B2-values of Bajpai’s equation derived from the Hamiltonian equation. The stability of ethanolic Argentum metallicum 100MK and Cantharis 100MK declined to 1/3 of their photons within a month in contrast to saccharose globules with Argentum metallicum 100MK having been stable during the period of these investigations for almost 1 year. Some remedies delivered as CMK potency had been proved to be ethanol. The testing amount of high ethanolic potencies is limited to 40 μl because 80 μl resulted in an attenuation of the photons; 40 μl equal 16 medicated saccharose globules. Six unknown homeopathic remedies could be identified as increasing potency levels of Argentum metallicum from 100MK to 1.000MK which indicates a calibration curve. The homeopathic factories having sent the unknown remedies confirmed the measurements. A quality control of homeopathic remedies is possible by comparing the different B2-values of the remedies and their carrier substances.


Homeopathy. 2014 Apr;103(2):127-32. doi: 10.1016/j.homp.2014.01.003.

Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles.

Bigagli E1, Luceri C2, Bernardini S3, Dei A4, Filippini A2, Dolara P2.

Author information

Abstract

BACKGROUND:

Diluted preparations obtained from Apis mellifica are reported in the homeopathic literature to have anti-inflammatory activity. The present study was designed to explore the effects on global gene expression profiles of human cells by means of microarrays, using Apis mellifica mother tincture (TM) and its 3C, 5C, 7C dynamized dilutions; the technique employed allowed us to study the changes in gene expression at concentrations much lower than those associated with pharmacological responses.

METHODS:

An RWPE-1 cell line (human immortalized prostate epithelial cells) was used to study the effects on global gene expression by transcriptomic analysis.

RESULTS:

Apis mellifica TM and its 3C, 5C, 7C dynamized dilutions modulated hundreds of genes; using cluster analysis we observed groups of genes up- or down-regulated with similar expression profiles among treatments; other genes showed opposite regulation profiles at low and high dilutions of Apis mellifica, suggesting a hormetic response. In particular, genes involved in cytokine expression, inflammatory processes, anti-oxidative responses and proteasome degradation were differentially, and sometimes divergently expressed by the TM or by Apis mellifica 3C, 5C and 7C dilutions. We confirmed these data by RT-PCR analyses on 5 selected candidate genes (IL1β, CD46, ATF1, UBE2Q2 and MT1X).

CONCLUSIONS:

Apis mellifica TM modifies gene expression in human cells and has inhibitory effects on regulatory processes of inflammation; in addition, extremely diluted dynamized dilutions (3C, 5C and 7C) still exert significant effects on genes involved in inflammation and oxidative stress.

Copyright © 2014 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.


Homeopathy. 2014 Oct;103(4):275-84. doi: 10.1016/j.homp.2014.08.002. Epub 2014 Oct 3.

Modulation of inflammation response to murine cutaneous Leishmaniosis by homeopathic medicines: Thymulin 5cH.

Rodrigues de Santana F1, Coelho Cde P1, Cardoso TN2, Laurenti MD3, Perez Hurtado EC2, Bonamin LV4.

Abstract

BACKGROUND:

In previous studies, we observed that thymulin 5cH could modulate BCG (Bacillus Calmette-Guerin) induced chronic inflammation by increasing peritoneal B1 stem cells differentiation into phagocytes and improving phagocytosis efficiency.

METHODS:

We used the same protocol to study the effects of thymulin 5cH in the experimental murine Leishmaniasis, in order to elucidate some aspects of the parasite-host relation under this homeopathic treatment. Male Balb/c mice were orally treated with thymulin 5cH or vehicle during 60 days, after the subcutaneous inoculation of 2 × 10(6) units of Leishmania (L.) amazonensis into the footpad. Washied inflammatory cell suspension from peritoneal cavity, spleen, local lymph node and infected subcutaneous tissue were harvested after 2 and 60 days from infection to quantify the inflammation cells by flow cytometry and histometry methods.

RESULTS:

After a transitory increase of peritoneal T reg cells, treated mice presented, chronically, increase in the peritoneal and spleen B1 cells percentage (p = 0.0001) in relation to other cell types; more organized and exuberant inflammation response in the infection site, and decrease in the number of parasites per field inside the primary lesion (p = 0.05). No difference was seen in local lymph node histology.

CONCLUSIONS:

Thymulin 5cH is able to improve B1 cell activation and Leishmania (L) amazonensis phagocytosis efficiency in mice, similarly to that observed previously in BCG experimental infection.

Copyright © 2014 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.


Homeopathy. 2014 Oct;103(4):224-31. doi: 10.1016/j.homp.2014.08.004. Epub 2014 Sep 27.

Efficacy of homeopathic intervention in subclinical hypothyroidism with or without autoimmune thyroiditis in children: an exploratory randomized control study.

Chauhan VK1, Manchanda RK2, Narang A3, Marwaha RK4, Arora S5, Nagpal L6, Verma SK7, Sreenivas V8.

Abstract

INTRODUCTION:

The decision to treat subclinical hypothyroidism (SCH) with or without autoimmune thyroiditis (AIT) in children, presents a clinical dilemma. This study was undertaken to evaluate the efficacy of individualized homeopathy in these cases.

METHODS:

The study is an exploratory, randomized, placebo controlled, single blind trial. Out of 5059 school children (06-18 years) screened for thyroid disorders, 537 children had SCH/AIT and 194 consented to participate. Based on primary outcome measures (TSH and/or antiTPOab) three major groups were formed: Group A – SCH + AIT (n = 38; high TSH with antiTPOab+), Group B – AIT (n = 47; normal TSH with antiTPOab+) and Group C – SCH (n = 109; only high TSH) and were further randomized to two subgroups-verum and control. Individualized homeopathy or identical placebo was given to respective subgroup. 162 patients completed 18 months of study.

RESULTS:

Baseline characteristics were similar in all the subgroups. The post treatment serum TSH (Group A and C) returned to normal limits in 85.94% of verum and 64.29% of controls (p < 0.006), while serum AntiTPOab titers (Group A and B) returned within normal limits in 70.27%of verum and 27.02%controls (p < 0.05). Eight children (10.5%) progressed to overt hypothyroidism (OH) from control group.

CONCLUSION:

A statistically significant decline in serum TSH values and antiTPOab titers indicates that the homeopathic intervention has not only the potential to treat SCH with or without antiTPOab but may also prevent progression to OH.

Copyright © 2014 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.


J Parasit Dis. 2014 Dec;38(4):417-9. doi: 10.1007/s12639-013-0269-6. Epub 2013 Mar 2.

Successful management of refractory cases of canine demodicosis with homeopathy medicine Graphitis.

Ranjan R1, Dua K2, Turkar S2, Singh H3, Singla LD3.

  • 1Department of Teaching Veterinary Clinical Complex, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141 004 Punjab India.
  • 2Department of Veterinary Medicine, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141 004 Punjab India.
  • 3Department of Veterinary Parasitology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141 004 Punjab India.

Abstract

Canine demodicosis is a refractory skin disease caused by excessive proliferation of mite Demodex canis. Despite availability of several treatment options, the disease poses a great challenge to clinicians for its long term management as some drugs may be ineffective or toxic. Present report describes successful treatment of two refractory cases of canine demodicosis using homeopathy medicine. After oral administration of Graphitis 200 C two drops once daily for 2 months, complete cure from the disease was observed. No adverse health effects of the medication were recorded during the treatment. Thus, it may be concluded that homeopathy medicine may be used safely for long-term management of canine demodicosis.


Complement Ther Clin Pract. 2014 Aug;20(3):141-6. doi: 10.1016/j.ctcp.2014.03.003. Epub 2014 Apr 8.

Additional effects of homeopathy on chronic periodontitis: a 1-year follow-up randomized clinical trial.

Mourão LC1, Cataldo DM2, Moutinho H2, Fischer RG3, Canabarro A4.

Abstract

BACKGROUND AND OBJECTIVE:

The aim of this study was test the hypothesis that homeopathy (H) enhances the effects of scaling and root planing (SRP) in patients with chronic periodontitis (CP).

MATERIALS AND METHODS:

50 patients with CP were randomly allocated to one of two treatment groups: SRP (C-G) or SRP + H (H-G). Assessments were made at baseline and after 3 and 12 months of treatments. The local and systemic responses to the treatments were evaluated by clinical and serologic parameters, respectively.

RESULTS:

Both groups displayed significant improvements, however, using clinical attachment gain and reductions in HDL, LDL and Total Cholesterol, Triglycerides, Glucose and Uric acid, from baseline to 1 year, as criteria for treatment success, H-G performed significantly better than C-G.

CONCLUSION:

The findings of this 1-year follow-up randomized clinical trial suggest that homeopathic medicines, as an adjunctive to SRP, can provide significant local and systemic improvements for CP patients.

Copyright © 2014 Elsevier Ltd. All rights reserved.


Urologe A. 2014 Nov;53(11):1661-3. doi: 10.1007/s00120-014-3588-z.

[Paralytic ileus after ileocystoplasty in a patient with spinal cord injury: is homeopathy helpful?].

[Article in German]

Pannek J1, Pannek-Rademacher S, Jus MC, Jus MS.

Abstract

A paralytic ileus is a typical complication of ileocystoplasty of the bladder. In patients with a spinal cord injury, this risk is higher due to a preexisting neurogenic bowel dysfunction. We present the case of a paraplegic man who developed a massive paralytic ileus after ileocystoplasty and surgical revision. Conventional stimulation of bowel function was unsuccessful; only by an adjunctive homeopathic treatment was normalization of bowel function achieved. Adjunctive homeopathic therapy is a promising treatment option in patients with complex bowel dysfunction after abdominal surgery who do not adequately respond to conventional treatment.


J Complement Integr Medorrhinum 2014 Sep;11(3):195-201.

Antiplasmodial potential of homeopathic drugs Chelidonium and nosode against Plasmodium berghei infection.

Bagai U, Walter NS.

Abstract

BACKGROUND:

Malaria remains a major global health concern in developing regions of the world. Homeopathy, a holistic system of medicine, has a lot to offer in protecting against malaria.

METHODS:

In the present study, antimalarial efficacy of combination of two homeopathic drugs Chelidonium 30 and nosode 30 has been evaluated in vivo against Plasmodium berghei (P. berghei) infection using Peters 4-day test. Biochemical assays have been performed to assess the levels of hepatic and renal function biomarkers upon drug treatment using diagnostic kits.

RESULTS:

The combination of the drugs demonstrated considerable in vivo antimalarial activity with chemosuppression of 91.45% on day 7. The combination also significantly (p < 0.0005) enhanced the mean survival time of mice which was calculated to be 22.5 ± 6.31 days, whereas it was 8.55 ± 0.83 days in infected control. The increase in levels of the liver function marker enzymes tested in serum of treated mice were significantly less (p < 0.0005) than those observed in infected control on day 10. The serum urea and creatinine used for assessment of renal sufficiency were slightly elevated above normal, but were statistically significant (p < 0.0005) as compared to infected control.

CONCLUSIONS:

The study establishes the effectiveness of the combination against P. berghei in vivo along with the safety of the drugs to the liver and kidney functions of the host.


Homeopathy. 2014 Apr;103(2):133-8. doi: 10.1016/j.homp.2013.08.006.

Anti-rheumatoid and anti-oxidant activity of homeopathic Guaiacum officinale in an animal model.

Sarkar A1, Datta P1, Das AK1, Gomes A2.

Abstract

BACKGROUND:

Homeopathy is a popular form of complementary and alternative medicine. Guaiacum extract is said to be useful for pain and inflammation, but there appears to be no scientific evidence to support this.

AIMS:

The aim of the present study was to evaluate the anti-rheumatic and anti-oxidant activity of homeopathic preparations of Guaiacum officinale (Gua) on experimental animal model.

DESIGN:

Rheumatoid arthritis (RA) was induced in male albino rats by Freund’s complete adjuvant (FCA) at a dose of (0.25 mg heat killed Mycobacterium tuberculosis/ml of emulsion). Gua mother tincture (MT) (prepared from the latex part of the plant) (MT), Gua 30cc and 200cc were purchased commercially from King Company, Kolkata, India. Male albino Wistar rats (130 ± 10 g) were divided into 6 groups: Sham control; Arthritis control; Standard treatment indomethacin (0.25 mg 100 g(-1) p.o. × 5 alternative days), Gua MT (1 ml kg(-1) p.o. × 5 days) treated; Gua (30c 1 ml kg(-1) p.o. × 5 days) treated; Gua (200c; 1 ml kg(-1) p.o. × 5 days) treated. Anti-rheumatic activity was examined through physical, urinary, serum parameters. All the results were expressed in terms of mean ± SEM (statistical error of mean n = 6) at each dose level. The level of significance was determined through one-way analysis of variance (ANOVA), p < 0.05 was considered significant.

RESULTS:

It was observed that body weight, ankle and knee diameter, urinary parameters (hydroxyproline (OH-P), glucosamine, calcium (Ca(2)(+)), creatinine (CRE), phosphate (PO4(3)(-)), serum ACP (acid phosphatase)/ALP (alkaline phosphatase)/Ca(2+)/CRE/PO4(3-)/gamma-glutamyl transferase (GGT)/Lipid peroxidation (LPO)/Glutathione (GSH)/Superoxide dismutase (SOD)/Catalase, serum GGT, serum interleukins like IL-1β/CINC-1/PGE2/TNF-α/IL-6, IL-12/IL-4/IL-6 levels were significantly affected. After treatment with Guaiacum in all 3 regimes was associated with normalization of these parameters compared to control group.

CONCLUSION:

These findings suggest that homeopathic G. officinale possesses anti-rheumatic and anti-oxidant activity in experimental animal and these activities may be more significant in higher potencies.


Homeopathy. 2014 Jan;103(1):44-50. doi: 10.1016/j.homp.2013.08.004.

Experimental evidence of stable water nanostructures in extremely dilute solutions, at standard pressure and temperature.

Elia V1, Ausanio G2, Gentile F3, Germano R4, Napoli E3, Niccoli M3.

Abstract

This paper presents the results of several experimental methods (FT-IR spectroscopy, UV-vis spectroscopy, fluorescence microscopy (FM), Atomic Force Microscopy (AFM)) evidencing structural changes induced in extremely diluted solutions (EDS), which are prepared by an iterated process of centesimal (1:100) dilution and succussion (shaking). The iteration is repeated until an extremely high dilution is reached, so that the composition of the solution becomes identical to that of the solvent–in this case water–used to prepare it. The experimental observations reveal the presence of supramolecular aggregates hundreds of nanometres in size in EDS at ambient pressure and temperature, and in the solid state. These findings confirm the hypothesis–developed thanks to previous physico-chemical investigations–that formation of water aggregates occurs in EDS. The experimental data can be analyzed and interpreted with reference to the thermodynamics of far-from-equilibrium systems and irreversible processes.

Copyright © 2013 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.


Homeopathy. 2014 Jan;103(1):44-50. doi: 10.1016/j.homp.2013.08.004.

Experimental evidence of stable water nanostructures in extremely dilute solutions, at standard pressure and temperature.

Elia V1, Ausanio G2, Gentile F3, Germano R4, Napoli E3, Niccoli M3.

Abstract

This paper presents the results of several experimental methods (FT-IR spectroscopy, UV-vis spectroscopy, fluorescence microscopy (FM), Atomic Force Microscopy (AFM)) evidencing structural changes induced in extremely diluted solutions (EDS), which are prepared by an iterated process of centesimal (1:100) dilution and succussion (shaking). The iteration is repeated until an extremely high dilution is reached, so that the composition of the solution becomes identical to that of the solvent–in this case water–used to prepare it. The experimental observations reveal the presence of supramolecular aggregates hundreds of nanometres in size in EDS at ambient pressure and temperature, and in the solid state. These findings confirm the hypothesis–developed thanks to previous physico-chemical investigations–that formation of water aggregates occurs in EDS. The experimental data can be analyzed and interpreted with reference to the thermodynamics of far-from-equilibrium systems and irreversible processes.

Copyright © 2013 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.

About the author

Alan V. Schmukler

Alan V. Schmukler

Alan V. Schmukler is a homeopath, Chief Editor of Homeopathy4Everyone and author of ”Homeopathy An A to Z Home Handbook”, (also available in French, German, Greek, Polish and Portuguese). He is Hpathy’s resident cartoonist and also produces Hpathy’s Tips & Secrets column and homeopathy Crossword puzzles each month. You can visit Alan at his website: www.healgently.com

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